Article
DNA repair defects associated with chromosomal translocation breaksite regions.
Molecular and cellular biology - 1 Feb 1994
Beecham E J, Jones G M, Link C, Huppi K, Potter M, Mushinski J F, Bohr V A
Abstract excerpt
Using an assay that measures the removal of UV-induced pyrimidine dimers in specific DNA sequences, we have found that the Pvt-1, immunoglobulin H-C alpha (IgH-C alpha), and IgL-kappa loci are poorly repaired in normal B lymphoblasts from plasmacytoma-susceptible BALB/cAnPt mice. Breaksites in th...
Topics
- Animals
- B-Lymphocytes
- Cells, Cultured
- Crosses, Genetic
- DNA
- DNA Repair
- DNA Replication
- Genes, Immunoglobulin
- Genes, abl
- Genetic Predisposition to Disease
- Immunity, Innate
- Immunoglobulin Switch Region
- Immunoglobulin kappa-Chains
- Mice
- Mice, Inbred BALB C
- Mice, Inbred DBA
- Plasmacytoma
- Pyrimidine Dimers