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Article

XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in <i>Igh</i> genes

3 Oct 2011

Abstract excerpt

Activation-induced deaminase (AID) deaminates cytosine to uracil in immunoglobulin genes. Uracils in DNA can be recognized by uracil DNA glycosylase and abasic endonuclease to produce single-strand breaks. The breaks are repaired either faithfully by DNA base excision repair (BER) or mutagenically to produce somatic hypermutation (SHM) and class switch recombination (CSR). To unravel the interplay between repair...

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PMID: 21967769
DOI: 10.1084/jem.20111135

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