Frequent p53 mutation in relapsed acute lymphoblastic leukemia with cytogenetic instability: a longitudinal analysis.

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Article

Frequent p53 mutation in relapsed acute lymphoblastic leukemia with cytogenetic instability: a longitudinal analysis.

Anticancer research - 1 Jan 2000

Tang J L, Tien H F, Lin M T, Chen P J, Chen Y C

Abstract excerpt

P53 mutation, through defects in repairing DNA damages, is associated with genomic instability. In 24 adult patients with relapsed acute lymphoblastic leukemia (ALL), the status of the p53 gene at different stages was serially followed by cytogenetic and polymerase-chain reaction/single strand co...

Topics

Adult
Chromosome Aberrations
Disease Progression
Female
Genes, p53
Humans
Karyotyping
Male
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recurrence

Source

Open in PubMed

Identifiers

PMID: 9615800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9615800-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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