A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets.

doi:10.1101/gad.8.1.33

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Article

A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets.

Genes & development - 1 Jan 1994

Kraut N, Frampton J, McNagny K M, Graf T

Abstract excerpt

Earlier work demonstrated that the Myb-Ets fusion protein of E26 avian leukemia virus induces the proliferation of multipotent hematopoietic progenitors (MEPs). These progenitors differentiate spontaneously at low frequencies along the erythroid lineage, and following the introduction of kinase/r...

Topics

Binding Sites
Cell Differentiation
Cell Transformation, Neoplastic
DNA
Gene Expression Regulation
Hematopoietic Stem Cells
Leukemia, Myelomonocytic, Acute
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-myb
Recombinant Fusion Proteins
Retroviridae Proteins, Oncogenic
Temperature
Tetradecanoylphorbol Acetate
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8288126
DOI: 10.1101/gad.8.1.33

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8288126-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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