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Article

A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets.

Genes & development - 1 Jan 1994

Kraut N, Frampton J, McNagny K M, Graf T

Abstract excerpt

Earlier work demonstrated that the Myb-Ets fusion protein of E26 avian leukemia virus induces the proliferation of multipotent hematopoietic progenitors (MEPs). These progenitors differentiate spontaneously at low frequencies along the erythroid lineage, and following the introduction of kinase/ras-type oncogenes or treatment with TPA, they are induced to differentiate along the myelomonocytic and eosinophilic...

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PMID: 8288126
DOI: 10.1101/gad.8.1.33

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets.PMID 8288126Read ↗

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Fusion of the nuclear oncoproteins v-Myb and v-Ets is required for the leukemogenicity of E26 virus.Semantic proximity Read ↗

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Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch.Semantic proximity Read ↗

Distinct C/EBP functions are required for eosinophil lineage commitment and maturation.Semantic proximity Read ↗

Myc Inhibits p27-Induced Erythroid Differentiation of Leukemia Cells by Repressing Erythroid Master Genes without Reversing p27-Mediated Cell Cycle ArrestSemantic proximity Read ↗

Thymomegaly, microsplenia, and defective homeostatic proliferation of peripheral lymphocytes in p51-Ets1 isoform-specific null mice.Semantic proximity Read ↗

Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.Semantic proximity Read ↗

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