v-Myb DNA binding is required to block thrombocytic differentiation of Myb-Ets-transformed multipotent haematopoietic progenitors.

doi:10.1002/j.1460-2075.1995.tb07286.x

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Article

v-Myb DNA binding is required to block thrombocytic differentiation of Myb-Ets-transformed multipotent haematopoietic progenitors.

The EMBO journal - 15 Jun 1995

Frampton J, McNagny K, Sieweke M, Philip A, Smith G, Graf T

Abstract excerpt

The E26 avian leukaemia virus encodes a fusion oncoprotein consisting of truncated versions of the c-Myb and c-Ets-1 transcription factors. When used to infect embryonic chicken haematopoietic cells two types of self-renewing progenitors are obtained, namely myeloblasts and 'MEPs' (Myb-Ets progenitors). In earlier work we have shown that myeloblasts transformed by the ts21 mutant of E26, which has a lesion in...

Topics

Acetyltransferases
Animals
Blood Platelets
Cell Differentiation
Cells, Cultured
Chick Embryo
DNA
DNA-Binding Proteins
Erythroid Precursor Cells
Hematopoiesis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Proteins v-myb

Promoter Regions, Genetic

Proteins

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-ets

Proto-Oncogene Proteins pp60(c-src)

Retroviridae Proteins, Oncogenic

Source

Open in PubMed Open full text

Identifiers

PMID: 7540977
DOI: 10.1002/j.1460-2075.1995.tb07286.x
PMCID: PMC398405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7540977-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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v-Myb DNA binding is required to block thrombocytic differentiation of Myb-Ets-transformed multipotent haematopoietic progenitors.PMID 7540977Read ↗

A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets.Semantic proximity Read ↗

v-myb and v-ets transform chicken erythroid cells and cooperate both in trans and in cis to induce distinct differentiation phenotypes.Semantic proximity Read ↗

Avian models to study the transcriptional control of hematopoietic lineage commitment and to identify lineage-specific genes.Semantic proximity Read ↗

Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.Semantic proximity Read ↗

Avian myeloblastic cell lines transformed by two nuclear oncoproteins, P135gag-myb-ets and p61/63myc: a model of retinoic acid-induced differentiation not abrogated by v-erbA.Semantic proximity Read ↗

Back-mutation of the V-Ets to the C-Ets carboxy-terminal amino acids in the P135gag-myb-ets results in chicken neuroretina cells transformation and loss of basic fibroblast growth factor responsiveness.Semantic proximity Read ↗

Fusion of the nuclear oncoproteins v-Myb and v-Ets is required for the leukemogenicity of E26 virus.Semantic proximity Read ↗

Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor.Semantic proximity Read ↗

Distinct C/EBP functions are required for eosinophil lineage commitment and maturation.Semantic proximity Read ↗

Transcriptional activation potential of normal and tumor-associated myb isoforms does not correlate with their ability to block GCSF-induced terminal differentiation of murine myeloid precursor cells.Semantic proximity Read ↗

Homodimerization of the Meq Viral Oncoprotein Is Necessary for Induction of T-Cell Lymphoma by Marek's Disease VirusSemantic proximity Read ↗

Transformation by v-myb correlates with trans-activation of gene expression.Semantic proximity Read ↗

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