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Article

Thymomegaly, microsplenia, and defective homeostatic proliferation of peripheral lymphocytes in p51-Ets1 isoform-specific null mice.

Molecular and cellular biology - 1 May 2007

Higuchi Tsukasa, Bartel Frank O, Masuya Masahiro, Deguchi Takao, Henderson Kelly W, Li Runzhao, Muise-Helmericks Robin C, Kern Michael J, Watson Dennis K, Spyropoulos Demetri D

Abstract excerpt

Ets1 is a member of the Ets transcription factor family. Alternative splicing of exon VII results in two naturally occurring protein isoforms: full-length Ets1 (p51-Ets1) and Ets1(DeltaVII) (p42-Ets1). These isoforms bear key distinctions regarding protein-protein interactions, DNA binding kinetics, and transcriptional target specificity. Disruption of both Ets1 isoforms in mice results in the loss of detectable...

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Identifiers

PMID: 17339335
DOI: 10.1128/MCB.01871-06
PMCID: PMC1899970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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