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Article

Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch.

Scientific reports - 9 Jun 2017

Norton Laura J, Hallal Samantha, Stout Elizabeth S, Funnell Alister P W, Pearson Richard C M, Crossley Merlin, Quinlan Kate G R

Abstract excerpt

The Krüppel-like factor (KLF) family of transcription factors play critical roles in haematopoiesis. KLF1, the founding member of the family, has been implicated in the control of both erythropoiesis and megakaryopoiesis. Here we describe a novel system using an artificial dominant negative isoform of KLF1 to investigate the role of KLF1 in the erythroid/megakaryocytic switch in vivo. We developed murine cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28600522
DOI: 10.1038/s41598-017-03289-5
PMCID: PMC5466599

Genes

KLF1

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