Article
Two rhombomeres are altered in Hoxa-1 mutant mice.
Development (Cambridge, England) - 1 Oct 1993
Mark M, Lufkin T, Vonesch J L, Ruberte E, Olivo J C, Dollé P, Gorry P, Lumsden A, Chambon P
Abstract excerpt
This study provides a detailed description of the anatomical defects in the Hoxa-1-/- mutant mice previously generated in our laboratory (T. Lufkin, A. Dierich, M. LeMeur, M. Mark and P. Chambon, 1991; Cell 66, 1105-1119). Three-dimensional reconstructions of the Hoxa-1-/- rhombencephalon reveals that it bears only five rhombomeric structures (ie. morphological segments) instead of the normal seven. The first...
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