Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6.

doi:10.1038/355516a0

Back to search

Article

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6.

Nature - 6 Feb 1992

Chisaka O, Musci T S, Capecchi M R

Abstract excerpt

Gene targeting in mouse embryo-derived stem cells has been used to generate mice with a disruption in the homeobox gene Hox-1.6. Mice heterozygous at the Hox-1.6 locus appear normal, whereas Hox-1.6-/Hox-1.6- mice die at or shortly after birth. These homozygotes exhibit profound defects in the fo...

Topics

Animals
Blotting, Southern
Chromosome Mapping
Cranial Nerves
Ear
Female
Genes, Homeobox
Genetic Vectors
Male
Mice
Mice, Inbred C57BL
Mutation
Pons
Rhombencephalon

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.