Article
Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants.
Development (Cambridge, England) - 1 Nov 1999
Barrow J R, Capecchi M R
Abstract excerpt
The rhombencephalic neural crest play several roles in craniofacial development. They give rise to the cranial sensory ganglia and much of the craniofacial skeleton, and are vital for patterning of the craniofacial muscles. The loss of Hoxa1 or Hoxa2 function affects the development of multiple neural crest-derived structures. To understand how these two genes function together in craniofacial development, an...
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