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Article

Chromatin structure of the EGFR gene suggests a role for intron 1 sequences in its regulation in breast cancer cells

1 Jan 1993

Abstract excerpt

The chromatin structure of the epidermal growth factor receptor gene (EGFR) has been analyzed in several human breast cancer cell lines exhibiting a wide range of EGFR expression. Using DNase I, structural differences were identified in the promoter, first exon, and intron 1 of the EGFR gene that correlate with its expression. Specifically, a DNase I hypersensitive site (DH site) around the exon 1/intron 1...

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PMID: 8284222
DOI: 10.1093/nar/21.24.5736

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