Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific down-regulation of an engineered human cyclin D1 promoter by a novel DNA-binding ligand in intact cells.

Nucleic acids research - 1 Feb 2001

Laurance M E, Starr D B, Michelotti E F, Cheung E, Gonzalez C, Tam A W, Deikman J, Edwards C A, Bardwell A J

Abstract excerpt

Cyclin D1 is expressed at abnormally high levels in many cancers and has been specifically implicated in the development of breast cancer. In this report we have extensively analyzed the cyclin D1 promoter in a variety of cancer cell lines that overexpress the protein and identified two critical regulatory elements (CREs), a previously identified CRE at -52 and a novel site at -30. In vivo footprinting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Cyclin D1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Luciferases

Share to Oligopeptides

Share to Regulatory Sequences, Nucleic Acid

Share to Sequence Deletion

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 11160886
DOI: 10.1093/nar/29.3.652
PMCID: PMC30392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific down-regulation of an engineered human cyclin D1 promoter by a novel DNA-binding ligand in intact cells.PMID 11160886Read ↗

A Novel Gene (PLU-1) Containing Highly Conserved Putative DNA/Chromatin Binding Motifs Is Specifically Up-regulated in Breast CancerSemantic proximity Read ↗

Functional promoter SNPs in cell cycle checkpoint genes.Semantic proximity Read ↗

A novel transcriptional inhibitory element differentially regulates the cyclin D1 gene in senescent cells.Semantic proximity Read ↗

Revisiting the role of MCL1 in tumorigenesis of solid cancer: gene expression correlates with antiproliferative phenotype in breast cancer cells and its functional regulatory variants are associated with reduced cancer susceptibility.Semantic proximity Read ↗

Chromatin structure of the EGFR gene suggests a role for intron 1 sequences in its regulation in breast cancer cellsSemantic proximity Read ↗

Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like elementSemantic proximity Read ↗

c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cellsSemantic proximity Read ↗

Identification of two evolutionarily conserved and functional regulatory elements in intron 2 of the human BRCA1 gene.Semantic proximity Read ↗

Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoterSemantic proximity Read ↗

Functional analysis of a mutant estrogen receptor isolated from T47Dco breast cancer cells.Semantic proximity Read ↗

Positive regulation of the BRCA1 promoter.Semantic proximity Read ↗

Heat shock protein B8, a cyclin-dependent kinase-independent cyclin D1 target gene, contributes to its effects on radiation sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.