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Article

A transcriptional enhancer required for the differential expression of the human estrogen receptor in breast cancers.

Molecular and cellular biology - 1 Mar 1997

Tang Z, Treilleux I, Brown M

Abstract excerpt

Breast cancers lacking estrogen receptor (ER) expression have an adverse prognosis and fail to respond to endocrine therapy. We have identified a transcriptional enhancer in the human ER gene which is differentially active in ER-positive (ER+) and ER-negative (ER-) human breast cancer cell lines. Enhancer function was mapped to a 35-bp element located from -3778 to -3744 upstream of the major human ER mRNA start...

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Identifiers

PMID: 9032254
DOI: 10.1128/MCB.17.3.1274
PMCID: PMC231852

Genes

ERF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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