Article
A transcriptional enhancer required for the differential expression of the human estrogen receptor in breast cancers.
Molecular and cellular biology - 1 Mar 1997
Tang Z, Treilleux I, Brown M
Abstract excerpt
Breast cancers lacking estrogen receptor (ER) expression have an adverse prognosis and fail to respond to endocrine therapy. We have identified a transcriptional enhancer in the human ER gene which is differentially active in ER-positive (ER+) and ER-negative (ER-) human breast cancer cell lines....
Topics
- Base Sequence
- Binding Sites
- Breast Neoplasms
- Carcinoma
- DNA Methylation
- DNA, Neoplasm
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Gene Expression Regulation, Neoplastic
- Humans
- Molecular Sequence Data
- Mutation