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Mechanisms of<i>egfr</i>Gene Transcription Modulation: Relationship to Cancer Risk and Therapy Response

15 Dec 2006

Abstract excerpt

The epidermal growth factor receptor (EGFR) plays a crucial role in growth, differentiation, and motility of normal as well as cancer cells. For predictive cancer diagnostics and therapeutic targeting of EGFR, it is important to know how the expression level of EGFR is controlled and related to receptor signaling. A novel transcriptional regulation mechanism has been described that depends on the length of a CA...

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PMID: 17189396
DOI: 10.1158/1078-0432.ccr-06-0626

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