Article
The atypical neuroleptic, clozapine, exerts antidystonic activity in a mutant hamster model. Comparison with haloperidol.
European journal of pharmacology - 5 Oct 1993
Richter A, Löscher W
Abstract excerpt
The effects of the atypical neuroleptic clozapine were studied in an inbred line of Syrian golden hamsters with generalized dystonia, i.e. a frequent movement disorder in humans. The effects of clozapine were compared with those of the classical neuroleptic, haloperidol. Clozapine, 7.5-20 mg/kg i...
Topics
- Animals
- Clozapine
- Cricetinae
- Disease Models, Animal
- Dystonia
- Female
- Haloperidol
- Male
- Mesocricetus
- Mutation