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Article

Behavioural effects of chronic haloperidol and risperidone treatment in rats.

Behavioural brain research - 10 Aug 2006

Karl Tim, Duffy Liesl, O'brien Elizabeth, Matsumoto Izuru, Dedova Irina

Abstract excerpt

The therapeutic properties of typical antipsychotic drugs (APDs) such as haloperidol in schizophrenia treatment are mainly associated with their ability to block dopamine D2 receptors. This blockade is accompanied by side effects such as extrapyramidal symptoms (EPS). Atypical APDs such as risperidone have superior therapeutic efficacy possibly due to their activity at multiple receptors (in particular 5-HT2A...

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Source

Identifiers

PMID: 16697060
DOI: 10.1016/j.bbr.2006.04.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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