Article
(+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamsters.
European journal of pharmacology - 3 Nov 1994
Richter A, Löscher W
Abstract excerpt
The effects of the novel high affinity cannabinoid receptor agonist (+)-WIN 55,212-2 ((R)-4,5-dihydro-2-methyl-4(4-morphoinylmethyl)-1-(1-naphthalen ylcarbonyl)-6H-pyrrolo[3,2,1-ij]quinolin-6-one) on severity of dystonia were investigated in mutant Syrian hamsters with primary generalized dystoni...
Topics
- Analgesics
- Animals
- Benzoxazines
- Cricetinae
- Diazepam
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Synergism
- Drug Therapy, Combination
- Dystonia
- Female
- Injections, Intraperitoneal
- Male
- Mesocricetus
- Morpholines
- Mutation
- Naphthalenes
- Receptors, Cannabinoid