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Article

DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody

1 Jan 1993

Abstract excerpt

The possibility of inducing an immune response to a protein expressed directly from an introduced gene represents an alternative to classic vaccination. We evaluated the ability of plasmid-based eukaryotic expression vectors to produce the Hepatitis B surface antigen (HBsAg) after injection of pure DNA into mouse tibialis anterior muscles. DNA was injected into either normal mature muscle, or regenerating muscle...

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Share to Hepatitis B Virus Studies
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Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8281146
DOI: 10.1093/hmg/2.11.1847

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