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Article

Autoimmune anemia in macaques following erythropoietin gene therapy

26 Jan 2004

Abstract excerpt

We delivered the homologous erythropoietin (Epo) cDNA driven from a doxycycline-regulated promoter via recombinant adeno-associated virus in skeletal muscle of 9 cynomolgus macaques. Upon induction, rapid supraphysiologic levels of Epo were obtained. Unexpectedly, some individuals developed a profound anemia that correlated with the appearance of neutralizing antibodies against the endogenous Epo. Both the...

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PMID: 14739218
DOI: 10.1182/blood-2003-11-3845

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