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Article

Gene vaccination with naked plasmid DNA: mechanism of CTL priming.

1 Oct 1996

Abstract excerpt

The injection of naked plasmid DNA directly into the muscle cells of mice has been shown to induce potent humoral and cellular immune responses. The generation of a cytotoxic T lymphocyte (CTL) response after plasmid DNA injection may involve the presentation of the expressed antigen in the context of the injected myocytes' endogenous major histocompatibility (MHC)-encoded class I molecules or may use the MHC...

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PMID: 8879229
DOI: 10.1084/jem.184.4.1555

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