Article
Intramuscular plasmid DNA injection can accelerate autoimmune responses.
Gene therapy - 1 Sept 2001
MacColl G, Bunn C, Goldspink G, Bouloux P, Górecki D C
Abstract excerpt
We have investigated if the administration of plasmid vectors engineered for gene delivery into mammalian muscle induced the production of anti-double stranded (ds) DNA and anti-nuclear autoantibodies in normal and autoimmunity-prone mouse models. In normal mice, repeated injection of plasmid DNA did not trigger an anti-DNA response. The presence of eukaryotic transcription factor binding sites in plasmid vectors...
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