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Plasmid DNA Malaria Vaccine: The Potential for Genomic Integration after Intramuscular Injection

20 Mar 1999

Abstract excerpt

Plasmid-based (naked DNA) genetic vaccines are now entering clinical trials to test their safety and efficacy in healthy human volunteers. A safety concern unique to this new class of vaccines is the potential risk of deleterious integration into host cell genomic DNA following direct intramuscular injection. To address this issue experimentally, a preclinical safety study was conducted in mice to determine the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10210143
DOI: 10.1089/10430349950018517

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