Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.

Cancer research - 15 Dec 2004

Bai Yunfeng, Edamatsu Hironori, Maeda Sakan, Saito Hiromitsu, Suzuki Noboru, Satoh Takaya, Kataoka Tohru

Abstract excerpt

Mutational activation of the ras proto-oncogenes is frequently found in skin cancers. However, the nature of downstream signaling pathways from Ras involved in skin carcinogenesis remains poorly understood. Recently, we and others identified phospholipase C (PLC) epsilon as an effector of Ras. Here we have examined the role of PLCepsilon in de novo skin chemical carcinogenesis by using mice whose PLCepsilon is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 9,10-Dimethyl-1,2-benzanthracene
Share to Carcinogens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phosphoinositide Phospholipase C

Share to ras Proteins

Share to Skin Neoplasms

Share to Tetradecanoylphorbol Acetate

Share to Type C Phospholipases

Source

Identifiers

PMID: 15604236
DOI: 10.1158/0008-5472.CAN-04-3143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.PMID 15604236Read ↗

Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.Semantic proximity Read ↗

Differential tumor biology effects of double-initiation in a mouse skin chemical carcinogenesis model comparing wild type versus protein kinase Cepsilon overexpression mice.Semantic proximity Read ↗

PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas.Semantic proximity Read ↗

Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.Semantic proximity Read ↗

Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol.Semantic proximity Read ↗

Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels.Semantic proximity Read ↗

Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.Semantic proximity Read ↗

Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.Semantic proximity Read ↗

p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.Semantic proximity Read ↗

CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.Semantic proximity Read ↗

ras protein p21 processing enzyme farnesyltransferase in chemical carcinogen-induced murine skin tumors.Semantic proximity Read ↗

Expression of enhancing factor/phospholipase A2 in skin results in abnormal epidermis and increased sensitivity to chemical carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.