Article
Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men.
Clinical pharmacology and therapeutics - 1 Dec 1993
Kinirons M T, O'Shea D, Downing T E, Fitzwilliam A T, Joellenbeck L, Groopman J D, Wilkinson G R, Wood A J
Abstract excerpt
In vitro studies with human liver microsomes have shown that erythromycin N-demethylation, dapsone N-hydroxylation, and the 6 beta-hydroxylation of cortisol are all primarily mediated by P4503A4. Trait measurements to assess the in vivo level of activity of these separate oxidations have also bee...
Topics
- Adult
- Aryl Hydrocarbon Hydroxylases
- Breath Tests
- Carbon Dioxide
- Carbon Radioisotopes
- Chemistry Techniques, Analytical
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- Dapsone
- Erythromycin
- Humans
- Hydrocortisone
- Hydroxylation
- Male
- Methylation