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Article

Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men.

Clinical pharmacology and therapeutics - 1 Dec 1993

Kinirons M T, O'Shea D, Downing T E, Fitzwilliam A T, Joellenbeck L, Groopman J D, Wilkinson G R, Wood A J

Abstract excerpt

In vitro studies with human liver microsomes have shown that erythromycin N-demethylation, dapsone N-hydroxylation, and the 6 beta-hydroxylation of cortisol are all primarily mediated by P4503A4. Trait measurements to assess the in vivo level of activity of these separate oxidations have also been developed previously. This study investigated the relationships among the three phenotypic trait measurements in 30...

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Source

Identifiers

PMID: 8275617
DOI: 10.1038/clpt.1993.199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men.PMID 8275617Read ↗

Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A.Semantic proximity Read ↗

Frequency distribution of dapsone N-hydroxylase, a putative probe for P4503A4 activity, in a white population.Semantic proximity Read ↗

Use of the erythromycin breath test for in vivo assessments of cytochrome P4503A activity and dosage individualizationSemantic proximity Read ↗

Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women.Semantic proximity Read ↗

Factors affecting cytochrome P-450 3A activity in cancer patients.Semantic proximity Read ↗

Evidence for the validity of cortisol 6 beta-hydroxylation clearance as a new index for in vivo cytochrome P450 3A phenotyping in humans.Semantic proximity Read ↗

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel: Lack of prediction by the erythromycin breath testSemantic proximity Read ↗

Gefitinib-phenytoin interaction is not correlated with the C-erythromycin breath test in healthy male volunteers.Semantic proximity Read ↗

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Only truncated, not complete cytochrome p450 2D6 RNA transcript and no detectable enzyme activity are expressed in human lymphocytes.Semantic proximity Read ↗

Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan.Semantic proximity Read ↗

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