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Article

Factors affecting cytochrome P-450 3A activity in cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2004

Baker Sharyn D, van Schaik Ron H N, Rivory Laurent P, Ten Tije Albert J, Dinh Kimberly, Graveland Wilfried J, Schenk Paul W, Charles Kellie A, Clarke Stephen J, Carducci Michael A, McGuire William P, Dawkins Fitzroy, Gelderblom Hans, Verweij Jaap, Sparreboom Alex

Abstract excerpt

PURPOSE: The purpose is to identify the demographic, physiologic, and inheritable factors that influence CYP3A activity in cancer patients. EXPERIMENTAL DESIGN: A total of 134 patients (62 females; age range, 26 to 83 years) underwent the erythromycin breath test as a phenotyping probe of CYP3A. Genomic DNA was screened for six variants of suspected functional relevance in CYP3A4 (CYP3A4*1B, CYP3A4*6, CYP3A4*17,...

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PMID: 15623611
DOI: 10.1158/1078-0432.CCR-04-1371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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