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Article

Gefitinib-phenytoin interaction is not correlated with the C-erythromycin breath test in healthy male volunteers.

British journal of clinical pharmacology - 1 Aug 2009

Chhun Stephanie, Verstuyft Celine, Rizzo-Padoin Nathalie, Simoneau Guy, Becquemont Laurent, Peretti Ilana, Swaisland Alan, Wortelboer Robert, Bergmann Jean Francois, Mouly Stephane

Abstract excerpt

AIMS: We aimed to describe the pharmacokinetic interaction between phenytoin, a potent CYP3A4 and P-glycoprotein (P-gp) (ABCB1) inducer, and gefitinib, a CYP3A4, CYP2D6 and P-gp substrate. METHODS: An open-label, randomized, two-phase crossover study was conducted. Eighteen healthy male volunteers (nine homozygous CC and nine homozygous TT as determined by their ABCB1 C3435T polymorphism in exon 26) received a...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19694743
DOI: 10.1111/j.1365-2125.2009.03438.x
PMCID: PMC2767287

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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