Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition.

doi:10.1177/0091270006287588

Article

Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition.

Journal of clinical pharmacology - 1 May 2006

Lee Su-Jun, Jusko William J, Salaita Christine G, Calis Karim A, Jann Michael W, Spratlin Vicky E, Goldstein Joyce A, Hon Yuen Yi

Abstract excerpt

The influence of diet and genetics was investigated in a healthy white person who had distinctly low methylprednisolone clearance. Pharmacokinetic and pharmacodynamic parameter values were similar on 2 occasions during the consumption of a low-carbohydrate diet and a Weight Watchers diet, indicating that the decreased clearance was unlikely attributable to a change in diet composition. Although the subject was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition.

Abstract excerpt

Topics

Related research