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Article

Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms.

Clinical pharmacology and therapeutics - 1 Jun 1995

Kim R B, O'Shea D

Abstract excerpt

Chlorzoxazone 6-hydroxylation is mediated by CYP2E1, and its measurement provides an in vivo probe of the enzyme's activity. To determine the population distribution of such activity, the disposition of chlorzoxazone and its 6-hydroxy metabolite was determined after oral administration to 70 white subjects (40 men and 30 women) residing in middle Tennessee. Both oral (330 +/- 111 ml.min-1, mean +/- SD) and...

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Identifiers

PMID: 7781264
DOI: 10.1016/0009-9236(95)90227-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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