Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms.

doi:10.1016/0009-9236(95)90227-9

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Article

Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms.

Clinical pharmacology and therapeutics - 1 Jun 1995

Kim R B, O'Shea D

Abstract excerpt

Chlorzoxazone 6-hydroxylation is mediated by CYP2E1, and its measurement provides an in vivo probe of the enzyme's activity. To determine the population distribution of such activity, the disposition of chlorzoxazone and its 6-hydroxy metabolite was determined after oral administration to 70 whit...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Chlorzoxazone
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
Female
Genotype
Humans
Hydroxylation
Male
Middle Aged
Molecular Sequence Data
Oxidoreductases, N-Demethylating
Polymorphism, Restriction Fragment Length
Sex Characteristics

Source

Open in PubMed

Identifiers

PMID: 7781264
DOI: 10.1016/0009-9236(95)90227-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7781264-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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