Article
Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation
3 Jul 1997
Abstract excerpt
We have examined several types of tumor cell lines and shown that they invariably expressed little or no Egr-1, in contrast to their normal counterparts. We have previously shown that the expression of exogenous Egr-1 in human breast and other tumor cells markedly reduces transformed growth and tumorigenicity. We therefore hypothesized that the loss of Egr-1 expression plays a role in transformation. All human...
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