Inhibition of human O6-methylguanine-DNA methyltransferase by 5-methylcytosine.

Article

Inhibition of human O6-methylguanine-DNA methyltransferase by 5-methylcytosine.

Cancer research - 15 Jan 1994

Bentivegna S S, Bresnick E

Abstract excerpt

The ability of cloned human O6-methylguanine-DNA methyltransferase to repair a methylated guanine in a CpG-containing sequence, i.e., island, was studied by using a synthetic double-stranded 20-mer oligonucleotide from codon 248 of the p53 gene and another designed sequence. The double-stranded o...

Topics

5-Methylcytosine
Base Sequence
Cytosine
DNA Repair
Genes, p53
Guanine
Humans
Methylation
Methyltransferases
Molecular Sequence Data
Mutation
O(6)-Methylguanine-DNA Methyltransferase

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