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Article

The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity.

Carcinogenesis - 1 Jul 1995

Edara S, Goodtzova K, Pegg A E

Abstract excerpt

The tyrosine residue present at position 158 in the human O6-alkylguanine-DNA alkyltransferase is one of 22 amino acid residues that are conserved in all known alkyltransferase protein sequences. The importance of this amino acid in the reactions brought about by the alkyltransferase was studied...

Topics

Alanine
Base Sequence
Binding Sites
DNA
Humans
Kinetics
Methyltransferases
Molecular Sequence Data
Mutation
O(6)-Methylguanine-DNA Methyltransferase
Phenylalanine
Structure-Activity Relationship
Tritium

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Tyrosine

Source

Identifiers

PMID: 7614699
DOI: 10.1093/carcin/16.7.1637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7614699-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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