Article
Leu 193 mutation in the cysteine rich region of the insulin receptor inhibits the cleavage of the insulin receptor precursor but not insulin binding.
Biochemical and biophysical research communications - 15 Sept 1994
Takata Y, Imamura T, Haruta T, Egawa K, Takada Y, Sawa T, Yang G H, Kobayashi M
Abstract excerpt
To characterize the Leu 193 mutant insulin receptor, which was found in a patient with extreme insulin resistance, the mutant insulin receptor was overexpressed in Rat-1 fibroblasts by transfection of mutated insulin receptor cDNA. In the pulse-chase experiment, the cleavage of the proreceptors to the matured receptor subunits was impaired in the cells expressing Leu 193 insulin receptor and therefore, the mutant...
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