Article
Microsatellite instability in childhood rhabdomyosarcoma is locus specific and correlates with fractional allelic loss.
Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996
Visser M, Bras J, Sijmons C, Devilee P, Wijnaendts L C, van der Linden J C, Voûte P A, Baas F
Abstract excerpt
Replication errors (RERs) were initially identified in hereditary nonpolyposis colon cancer and other tumors of Lynch syndrome II. Mutations in genes involved in mismatch repair give rise to a mutator phenotype, resulting in RERs. The mutator phenotype is thought to predispose to malignant transformation. Here we show that in the embryonal form of childhood rhabdomyosarcoma, RERs also occur, but in contrast to...
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