Article
Nuclear matrix proteins distinguish normal diploid osteoblasts from osteosarcoma cells.
Cancer research - 1 Jan 1994
Bidwell J P, Fey E G, van Wijnen A J, Penman S, Stein J L, Lian J B, Stein G S
Abstract excerpt
Interrelationships between nuclear architecture and gene expression were examined by comparing the representation of nuclear matrix proteins in ROS 17/2.8 rat and MG-63 human osteosarcoma cells with those in normal diploid osteoblasts. The tumor-derived cells coexpress genes which are expressed i...
Topics
- Animals
- Antigens, Nuclear
- Biomarkers, Tumor
- Cell Differentiation
- Female
- Gene Expression Regulation, Neoplastic
- Nuclear Proteins
- Osteoblasts
- Osteosarcoma
- Phenotype
- Pregnancy
- Rats
