Article
A novel estrogen receptor variant mRNA lacking exons 4 to 6 in breast carcinoma.
The Journal of steroid biochemistry and molecular biology - 1 Aug 1997
Chan C M, Dowsett M
Abstract excerpt
A novel estrogen receptor mRNA splice variant which lacks the entire exon 5 and part of exon 4 and 6 was identified using reverse transcription PCR in human breast carcinomas. The variant was translated in vitro and produced a protein of approximately Mr 31000 which lacked the ligand binding doma...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Breast Neoplasms
- CHO Cells
- Cricetinae
- DNA Primers
- Drug Resistance
- Estrogen Antagonists
- Exons
- Female
- Genetic Variation
- Humans
- Molecular Sequence Data
- Neoplasms, Hormone-Dependent
- Polymerase Chain Reaction
- RNA Splicing
- RNA, Messenger