Identification of wild-type and exon 5 deletion variants of estrogen receptor beta in normal human mammary gland.

doi:10.1210/jcem.85.4.6493

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Article

Identification of wild-type and exon 5 deletion variants of estrogen receptor beta in normal human mammary gland.

The Journal of clinical endocrinology and metabolism - 1 Apr 2000

Speirs V, Adams I P, Walton D S, Atkin S L

Abstract excerpt

We have examined messenger RNA (mRNA) expression of estrogen receptor (ER) alpha, wild-type ERbeta (mRNA and protein), and ERbeta exon 5 deletion variants (ERbeta delta5) in samples of normal human mammary gland obtained from 37 premenopausal subjects undergoing reduction mammoplasty. Comparing individual expression, ERbetaP mRNA predominated, expressed in 34 of 37 samples (91%), whereas ERalpha was found in 21...

Topics

Adolescent
Adult
Breast
Estrogen Receptor alpha
Estrogen Receptor beta
Exons
Female
Gene Deletion
Gene Expression
Genetic Variation
Humans
Immunohistochemistry
RNA, Messenger
Receptors, Estrogen
Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 10770204
DOI: 10.1210/jcem.85.4.6493

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