Article
Prevalence of estrogen receptor variant messenger RNAs in human breast cancer.
Cancer research - 1 Oct 1996
Leygue E, Huang A, Murphy L C, Watson P H
Abstract excerpt
A new approach, based on the competitive amplification of wild-type and exon-deleted estrogen receptor (ER) variant cDNAs, was used to screen 100 human breast tumors for the presence of ER variants. Already described exon 4-deleted ER mRNA was preferentially detected in tumors with lower grades (P < 0.05) or higher progesterone receptor levels (P < 0.01), whereas new ER variants, deleted in exons 2-4 or in...
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