Article
Somatic mutation in autoantibody-associated VH genes of circulating IgM+IgD+ B cells.
European journal of immunology - 1 May 1998
Munakata Y, Saito S, Hoshino A, Muryoi T, Hirabayashi Y, Shibata S, Miura T, Ishii T, Funato T, Sasaki T
Abstract excerpt
Naive B cells expressing IgM and IgD on their surface have no or little somatic mutations in V genes. We have demonstrated that the human IgM+IgD+B cell clone (0-81), which expresses nephritogenic idiotypes, produces IgM anti-DNA antibodies which show monospecificity to DNA. Using a DNA probe whi...
Topics
- Amino Acid Sequence
- Autoantibodies
- B-Lymphocyte Subsets
- Base Sequence
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Germ Cells
- Humans
- Immunoglobulin D
- Immunoglobulin Heavy Chains
- Immunoglobulin M
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation