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Article

Immunobiologic and biochemical properties of mutants of toxic shock syndrome toxin-1.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1994

Murray D L, Prasad G S, Earhart C A, Leonard B A, Kreiswirth B N, Novick R P, Ohlendorf D H, Schlievert P M

Abstract excerpt

Toxic shock syndrome (TSS) is a multisystem illness caused mainly by Staphylococcus aureus producing TSS toxin-1 (TSST-1). A variant of TSST-1 has been isolated from ovine mastitis S. aureus. This toxin, TSST-ovine (TSST-O) is only weakly T cell mitogenic, is nonpyrogenic, does not enhance endotoxin shock, and does not cause TSS in the miniosmotic pump model. The sequence of the ovine gene (tstO) differs from the...

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PMID: 8254210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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