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Article

Immunobiologic and biochemical properties of mutants of toxic shock syndrome toxin-1.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1994

Murray D L, Prasad G S, Earhart C A, Leonard B A, Kreiswirth B N, Novick R P, Ohlendorf D H, Schlievert P M

Abstract excerpt

Toxic shock syndrome (TSS) is a multisystem illness caused mainly by Staphylococcus aureus producing TSS toxin-1 (TSST-1). A variant of TSST-1 has been isolated from ovine mastitis S. aureus. This toxin, TSST-ovine (TSST-O) is only weakly T cell mitogenic, is nonpyrogenic, does not enhance endotoxin shock, and does not cause TSS in the miniosmotic pump model. The sequence of the ovine gene (tstO) differs from the...

Topics

Amino Acid Sequence
Animals
Bacterial Toxins
Base Sequence
Enterotoxins
Mitogens
Molecular Sequence Data
Mutation
Protein Structure, Secondary
Rabbits
Recombinant Fusion Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Amino Acid

Shock, Septic

Staphylococcus aureus

Structure-Activity Relationship

Superantigens

Source

Identifiers

PMID: 8254210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8254210-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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