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Staphylococcal superantigen (TSST-1) mutant analysis reveals that t cell activation is required for biological effects in the rabbit including the cytokine storm.

Toxins - 1 Sept 2010

Stich Norbert, Waclavicek Martina, Model Nina, Eibl Martha M

Abstract excerpt

Staphylococcal superantigens (sAgs), such as toxic shock syndrome toxin 1 (TSST-1), induce massive cytokine production, which may result in toxic shock syndrome (TSS) and sepsis. Recently, we reported that in vitro studies in human peripheral blood mononuclear cells (PBMC) do not reflect the immunological situation of the host, because after exposure to superantigens (sAgs) in vivo, mononuclear cells (MNC) leave...

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Identifiers

PMID: 22069685
DOI: 10.3390/toxins2092272
PMCID: PMC3153295

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