Article
A toxic shock syndrome toxin 1 mutant that defines a functional site critical for T-cell activation.
Infection and immunity - 1 Jun 1995
Cullen C M, Blanco L R, Bonventre P F, Choi E
Abstract excerpt
Toxic shock syndrome toxin 1 (TSST-1), a superantigen produced by Staphylococcus aureus, is a causative agent of toxic shock syndrome (TSS). This superantigen is a potent stimulator of T cells and macrophages/monocytes, resulting in the release of cytokines that are implicated in the pathogenesis...
Topics
- Animals
- Bacterial Toxins
- Base Sequence
- Enterotoxins
- Histocompatibility Antigens Class II
- Interferon-gamma
- Interleukin-2
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Staphylococcus aureus
- Structure-Activity Relationship
- Superantigens
- T-Lymphocytes
- Tumor Necrosis Factor-alpha