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Article

Novel toxic shock syndrome toxin-1 amino acids required for biological activity.

Biochemistry - 9 Dec 2008

Brosnahan Amanda J, Schaefers Matthew M, Amundson William H, Mantz Mary J, Squier Christopher A, Peterson Marnie L, Schlievert Patrick M

Abstract excerpt

Superantigens interact with T lymphocytes and macrophages to cause T lymphocyte proliferation and overwhelming cytokine production, which lead to toxic shock syndrome. Staphylococcus aureus superantigen toxic shock syndrome toxin-1 is a major cause of menstrual toxic shock syndrome. In general, superantigen-secreting S. aureus remains localized at the vaginal surface, and the superantigen must therefore penetrate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19012411
DOI: 10.1021/bi801468w
PMCID: PMC2645936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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