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Article

Pharmacological knockout of endothelin ET(A) receptors.

Life sciences - 5 Dec 2003

Taniguchi Takanobu, Muramatsu Ikunobu

Abstract excerpt

We employed newly developed antagonists, which are specific for endothelin ET(A) receptors, to test whether this drug could mimic the phenotype of the mouse with corresponding gene knock out. Newborn rats, whose dams were given the ET(A) antagonist from day 7 of gestation, exhibited the typical ET(A)-lacking phenotypes like craniofacial abnormalities and major vessel anomalies. Interestingly, craniofacial...

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Source

Identifiers

PMID: 14607269
DOI: 10.1016/j.lfs.2003.09.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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