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HTLV-1 Viral Factor HBZ Induces CCR4 to Promote T-cell Migration and Proliferation

12 Jul 2016

Abstract excerpt

Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and other inflammatory diseases in infected individuals. However, a complete understanding of how HTLV-1 transforms T cells is lacking. Expression of the chemokine receptor CCR4 on ATL cells and HTLV-1-infected cells suggested the hypothesis that CCR4 may mediate features of ATL and inflammatory diseases caused by HTLV-1. In...

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PMID: 27402079
DOI: 10.1158/0008-5472.can-16-0361

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