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Article

Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene.

FEBS letters - 11 Feb 2003

Zhao Jiangqin, Bilsland Alan, Hoare Stacey F, Keith W Nicol

Abstract excerpt

The proximal promoter of the telomerase RNA gene, hTR, contains four Sp1 sites and one CCAAT box. We have carried out a functional analysis of the role of these sequence elements. Two Sp1 sites downstream of the CCAAT box mediated negative regulation, while the other two Sp1 sites were positive regulators with the strongest effect mediated by the negative regulatory Sp1 site closely flanking the CCAAT box. Basal...

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Identifiers

PMID: 12586348
DOI: 10.1016/s0014-5793(03)00038-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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