Structure, function, and biogenesis of SecY, an integral membrane protein involved in protein export.

Abstract excerpt

The E. coli secY (prlA) gene, located in the operator-distal part of the spc ribosomal protein operon, codes for an integral membrane protein, SecY. The phenotypes of temperature-sensitive and cold-sensitive mutations in secY suggest that the SecY protein plays an essential role in vivo to facilitate protein translocation, whereas the prlA mutations in this gene suggest that SecY may interact with the signal...

Topics

• Bacterial Proteins
• Biological Transport, Active
• Escherichia coli
• Escherichia coli Proteins
• Membrane Proteins
• Molecular Conformation
• Mutation
• SEC Translocation Channels