Article
Contrasting methods of quantifying fine structure of human recombination.
Annual review of genomics and human genetics - 1 Jan 2010
Clark Andrew G, Wang Xu, Matise Tara
Abstract excerpt
There has been considerable excitement over the ability to construct linkage maps based only on genome-wide genotype data for single nucleotide polymorphic sites (SNPs) in a population sample. These maps, which are derived from estimates of linkage disequilibrium (LD), rely on population genetics theory to relate the decay of LD to the local rate of recombination, but other population processes also come into...
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