Article
Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins.
Trends in pharmacological sciences - 1 Aug 1993
Lefkowitz R J, Cotecchia S, Samama P, Costa T
Abstract excerpt
Adrenoceptors are prototypic members of the superfamily of seven transmembrane domain, G protein-coupled receptors. Study of the properties of several mutationally activated adrenoceptors is deepening understanding of the normal functioning of this ubiquitous class of receptors. The new findings suggest an expansion of the classical ternary complex model of receptor action to include an explicit isomerization of...
Topics
- Amino Acid Sequence
- Animals
- GTP-Binding Proteins
- Models, Chemical
- Molecular Sequence Data
- Mutation
- Receptors, Cell Surface
- Stereoisomerism
- Structure-Activity Relationship