Article

In silico study on RNA structures of intronic mutations of beta-globin gene

2020-09-01

Abstract excerpt

<h4>Background: </h4> Mutation of the beta-globin gene (HBB) interferes with primary mRNA transcription, leading to beta-thalassemia disease. The IVS1nt1 and IVS1nt5 mutations were reported as two of the most prevalent intronic mutations associated with beta-thalassemia major. These mutations may affect the mRNA structure of the human beta-globin ( HBB ) gene. However, the mechanism by which variation in HBB alte...

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Literature Corpus work: 3284d5cb-04fe-5a9c-bdca-1817847e22b9
DOI: 10.12688/f1000research.21953.3

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