Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The +1,506 (A>C) mutation in the 3' untranslated region affects β-globin expression.

Hemoglobin - 1 Jan 2012

Hino Minako, Ito Hitomi, Yamashiro Yasuhiro, Hattori Yukio, Nitta Takenori, Adhiyanto Chris

Abstract excerpt

The 3' untranslated region (3'UTR) is known to be important to mRNA stability but the stabilization mechanism on the β-globin gene is not fully elucidated. We speculated in our previous report that +1,506 (A>C) mutation (HGVS nomenclature: *32A>C) on the β-globin 3'UTR causes β-thalassemia (β-thal) in order to destabilize the mRNA. To investigate further, we studied the expression efficiency for the mutation with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to beta-Globins
Share to beta-Thalassemia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to K562 Cells

Share to Luciferases

Share to Nucleic Acid Conformation

Share to Recombinant Fusion Proteins

Share to RNA Stability

Source

Identifiers

PMID: 22734587
DOI: 10.3109/03630269.2012.698341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The +1,506 (A>C) mutation in the 3' untranslated region affects β-globin expression.PMID 22734587Read ↗

Identification of a novel mutation in the β-globin gene 3' untranslated region [+1,506 (A>C)] in a Japanese male with a heterozygous β-thalassemia phenotype.Semantic proximity Read ↗

Evaluation of the Function of a Rare Variant in the 3'-Untranslated Region of the β-Globin Gene.Semantic proximity Read ↗

First Report of the 3'-Untranslated Region +1506 (A>C) [NM_000518.5: c.*32A>C] mutation on the β-Globin Gene in the Indian Population.Semantic proximity Read ↗

A +8 (-->CT) mutation within the 5' untranslated region of beta-globin down-regulates the mRNA transcription.Semantic proximity Read ↗

β-Thalassemia Intermedia Caused by the β-Globin Gene 3' Untranslated Region: Another Case Report.Semantic proximity Read ↗

Two Novel and Five Rare Mutations in the Non Coding Regions of the β-Globin Gene in the Iranian Population.Semantic proximity Read ↗

Thalassaemia mutations within the 5'UTR of the human beta-globin gene disrupt transcription.Semantic proximity Read ↗

Presentation of two new mutations in the 3'untranslated region of the β-globin gene and evaluating the molecular spectrum of thalassemia mutations in the Mediterranean region of Turkey.Semantic proximity Read ↗

Association in cis of the mutations +20 (C>T) in the 5' untranslated region and IVS-II-745 (C>G) on the β-globin gene.Semantic proximity Read ↗

In silico study on RNA structures of intronic mutations of beta-globin geneSemantic proximity Read ↗

Thalassemia major phenotypes secondary to the association of β 5'UTR +20(C → T) allele with β 39(C → T).Semantic proximity Read ↗

Identification of a Novel Mutation in the 3' Untranslated Region of the β-Globin Gene (HBB:c.*132C>G) in a Chinese Family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.